University of Wisconsin–Madison

MR Hysterography in the Evaluation of Dysfunctional Uterine Bleeding in Women

June 2005 to December 2007

The goal of this study is to demonstrate that T1-weighted 3D FSPGR and T2-weighted 3D FSE MRI of the uterus will be as sensitive as saline infused sonohysterography (SIS) in identifying endometrial lesions and will be superior to SIS in determining their malignant potential. It is believed that MRI will provide a minimally invasive, cost effective means of evaluating women with dysfunctional uterine bleeding to characterize endometrial lesions. Previous studies have shown that MRI can differentiate between benign polyps and endometrial carcinomas using T2- and T1-weighted images.

MR Protocol: The MR protocol will consist of acquisition of T1-weighted 3D FSPGR and T2-weighted 3D FSE sequences pre-gadolinium injection. The T1-weighted sequence will use the standard clinical protocol. The T2-weighted sequence will use thinner slices and a smaller FOV than the standard clinical protocol to achieve improved spatial resolution. During injection of 0.1 mmol/kg gadolinium contrast agent, a time-resolved T1-weighted sequence will be run for 5 minutes. Following this, a final static T1-weighted imaging sequence will be performed. Perfusion analysis will be conducted using the time-resolved image set.

This project led by: Elizabeth Sadowski, MD