University of Wisconsin–Madison

Magnetic Resonance Imaging Protocol Development

December 2016 to March 2021

The purpose of this study is to evaluate, compare, and optimize MRI scanner performance as a function of pulse sequences, scanning parameters, image reconstruction or analysis software, and hardware. We expect to improve scientific studies by either increasing effect sizes or decreasing variance in addition to providing measures previously unavailable. We will examine methods that include measuring brain structural anatomy, tissue microstructural properties (diffusion, T1 and T2 relaxation rates, magnetization transfer, MR spectroscopy), blood or CSF flow (angiography and perfusion methods), and functional MRI (BOLD or ASL). We will also investigate the variability of the imaging measures over time and between scanners.

This project led by: Andrew Alexander PhD