University of Wisconsin–Madison

Fat Quantification with MRI

This project was led by: Scott B Reeder MD, PhD

This project was funded by: NIH

The term of this project was: January 2016 to May 2019

The number of subjects scanned during this project was: 100

The primary purpose of this community-based longitudinal clinical research project is to investigate the evolving relationship between site-specific adiposity – including liver fat – with insulin resistance (IR) during puberty. Three cohorts of 20 middle-school aged girls will be followed twice yearly for 3 years during grades 6, 7, and 8. At every visit (fall and spring) six tasks will be performed, including MRI, serum labs, morphometric measurements, Tanner self-staging pubertal development survey, and a health information survey. Subject fitness will be obtained using Progressive Aerobic Cardiovascular Endurance Race (PACER) scores routinely performed as part of the school curriculum twice per year.