The primary purpose of this community-based longitudinal clinical research project is to investigate the evolving relationship between site-specific adiposity – including liver fat – with insulin resistance (IR) during puberty. Three cohorts of 20 middle-school aged girls will be followed twice yearly for 3 years during grades 6, 7, and 8. At every visit (fall and spring) six tasks will be performed, including MRI, serum labs, morphometric measurements, Tanner self-staging pubertal development survey, and a health information survey. Subject fitness will be obtained using Progressive Aerobic Cardiovascular Endurance Race (PACER) scores routinely performed as part of the school curriculum twice per year.
January 2016 to May 2019
This project led by: Scott B Reeder, MD, PhD