University of Wisconsin–Madison

Wisconsin Alzheimer’s Disease Research Center (Wisconsin ADRC) MRI Study

March 2010 to March 2014

The broad research goals of the Wisconsin Alzheimer’s Disease Research Center (Wisconsin ADRC) are to promote preclinical diagnosis of Alzheimer’s disease (AD) and identification of early intervention and prevention strategies. The goal is to establish a pool of patients to support translational research in dementia. This Wisconsin ADRC Clinical Core will consist of 5 subgroups: 1) patients with mild late-onset AD, 2) patients with mild cognitive impairment (MCI), 3) age-matched healthy older controls, 4) middle-aged adults with a parental history of AD (parental history positive; PH+), and 5) middle-aged adults whose father survived to 70 and mother 75 without signs or symptoms of dementia (parental history negative; PH-). Each participant will be asked to participant in an MRI at their baseline visit. The MRI is an optional procedure. Specific neuroimaging data that will be collected include a 3D T1-weighted volumetric scan, a 6-minute whole-brain perfusion scan with arterial spin labeling, and a new 3D high resolution FLAIR scan.

This project led by: Sanjay Asthana, MD