The primary aim of this study is to develop a robust, full-chest, high spatial resolution, high temporal resolution pulmonary perfusion MRI method that could fill a variety of clinical and research needs. We have recently developed a new method for perfusion MRI (called Highly-constrained Cartesian Reconstruction, HYCR) and early results have been very promising. A primary source of artifact, however, is cardiac motion. In this study we will investigate different methods of mitigating cardiac motion artifact in up to 12 normal volunteers and then compare the best of these methods with alternative, existing pulmonary perfusion methods in up to 24 normal volunteers.
August 2010 to July 2012