This purpose of this work is to optimize the rapid, 3D radial MRI pulse sequence known as Vastly undersampled Isotropic Projection Reconstruction, or VIPR, for Dynamic Contrast Enhanced (DCE) breast MRI with high spatial and temporal resolution and robust fat suppression. The DCE sequence is the centerpiece of the MR breast exam and is used for breast cancer detection and diagnosis, evaluation of extent of disease, and for measuring treatment response in patients undergoing neoadjuvant chemotherapy. The improved temporal resolution provided by the VIPR acquisition could allow for the development of noninvasive, quantitative, imaging based biomarkers of malignancy that could be used in detection and diagnosis or in the early evaluation of treatment response.
March 2015 to March 2016
This project led by: Roberta Strigel, MD