University of Wisconsin–Madison

EXERT: Therapeutic Effects of Exercise in Adults with Amnestic Mild Cognitive Impairment

June 2017 to June 2019

EXERT is a phase 3, multicenter, randomized single-blind study to examine the effects of aerobic exercise on cognition, functional status, whole and regional brain atrophy, whole and regional cerebral blood flow, and cerebrospinal fluid biomarkers of Alzheimer’s disease in 300 adults with amnestic mild cognitive impairment (MCI). The study is taking place at 14 academic medical centers and YMCAs in the US. EXERT will examine whole brain and regional changes in structure and blood flow as measured by brain magnetic resonance imaging (MRI). This study will test whether 12 months of supervised aerobic exercise can attenuate disease-related atrophy and increase perfusion in hippocampal, prefrontal, and posterior parietal regions that support memory and executive function.

This project led by: Ozioma Okonkwo, PhD