University of Wisconsin–Madison

Evaluation of a Novel Time-Resolved Liver Imaging Method

October 2013 to December 2013

Contrast enhanced MR imaging of the liver is used routinely in the clinic for detecting and characterizing liver lesions including hepatocellular carcinomas (HCC). In the current clinical standard, a pre-contrast image is acquired during a breath hold followed by three identical scans at different times after the injection of contrast – each in a separate breath hold. The goal of this study is to develop and validate an MRI method to replace the first of these three post-contrast breath hold images with a dynamic series of images to better capture the temporal changes of lesion contrast within the breath-hold period. An interleaved variable density sampling pattern is used with view-sharing reconstruction to accelerate imaging and acquire a volumetric high spatial resolution image of the liver every 4-6 seconds. During the first phase of this project, technical developments to this sequence are tested in a group of 10 individuals with known focal nodular hyperplasia (FNH).

This project led by: Frank R Korosec, PhD