The Epilepsy Connectome Project (ECP) will collect detailed connectivity measurements in the brains of 100 people with idiopathic temporal lobe epilepsy (TLE), and 15 control subjects, using diffusion-weighted magnetic resonance imaging of structural connections, functional magnetic resonance imaging of dynamic network interactions, and magnetoencephalography to measure these interactions with millisecond time resolution. The methods will closely mirror those currently used by the Human Connectome Project (HCP) to study network connectivity in the brains of healthy participants, and the HCP data will provide a critical baseline against which to compare the ECP connectome data. These comparisons, based on large cohorts studied with sensitive, state-of-the-art methods, will reveal for the first time the full extent of abnormal network structure and function in the brains of patients with temporal lobe epilepsy.
September 2015 to September 2019
This project led by: Elizabeth Meyerand, PhD