University of Wisconsin–Madison

DISCO Breast Imaging at 1.5 T Compared with Clinical Standard-of-Care Breast MRI

November 2013 to November 2014

An integral part of clinical breast MRI exams is a dynamic contrast-enhanced sequence that is used to detect breast lesions and characterize enhancement over time. The current clinical sequence favors spatial resolution at the cost of temporal resolution. The purpose of this study is to validate a new sequence, DIfferential Subsampling with Cartesian Ordering (DISCO), in order to replace the current clinical dynamic contrast-enhanced sequence. DISCO uses a unique k-space segmentation that is able to improve the temporal resolution while maintaining high spatial resolution. The high temporal resolution could allow for better characterization of lesion enhancement as well as allow for calculations of quantitative pharmacokinetic biomarkers needed in the clinical and research setting. This study will recruit 30 patients who have had a diagnostic clinical breast MRI displaying enhancement which could be well depicted with time-resolved breast MRI.

This project led by: Roberta Strigel, MD