University of Wisconsin–Madison

Diagnosis of gout with dual-energy computed tomography using virtual monochromatic spectral imaging with fast kilovoltage switching and a single x-ray source: an accuracy and diagnostic yield study

The PI of this project is: B. Keegan Markhardt MD

This project is funded by: Radiology RD

The term of this project is: July 2015 to June 2017

The number of subjects scanned during this project is: 294

The aim of this study is to validate a new and noninvasive technique for the diagnosis of gout. We hope that this technique will aid in the diagnosis of gout, and potentially replace invasive needle aspiration of joints. This information may be helpful in understanding the natural history of gouty arthritis, as the amount of MSU deposition in asymptomatic joints during asymptomatic hyperuricemia and at the initial acute gout monoarthropathy has been difficult to study. Understanding the total MSU deposit burden could serve as a potential guide for clinical management and assess treatment response.
Subjects will be asked to complete a DECT scan at the Wisconsin Institutes for Medical Research (WIMR). Subjects will have a single DECT scan of the affected joint that will take approximately 10 minutes to complete.