University of Wisconsin–Madison

Comparison of Pulmonary MR-Angiography and Ultrashort Echo Time MRI with Gadolinium and Ferumoxytol for the Depiction of the Pulmonary Vasculature

This project was led by:

This project was funded by: Radiology RD

The term of this project was: March 2017 to October 2017

The number of subjects scanned during this project was: 20

Pulmonary MRA is an emerging technique to detect pulmonary embolism without the use of ionizing radiation. This technique is capable of achieving high quality angiograms in approximately 75% of the cases. However, a subset of patients fails the breathholding required for pulmonary MRA. To overcome this limitation, free-breathing ultrashort echo time (UTE) imaging of the pulmonary vasculature has been introduced recently. Due to the longer scan time of the free breathing UTE sequence, a blood pool contrast agent is beneficial in order to achieve constant high intravascular signal throughout the scan.

Ferumoxytol is a contrast agent that is increasingly used due to its excellent magnetic properties and the lack of gadolinium. Ferumoxytol is an effective blood pool contrast agent with an intravascular half-life of 14-15 hours.

The purpose of this study is to compare pulmonary MRA and UTE imaging with gadobenate dimeglumine and ferumoxytol in order to evaluate if a comparable image quality can be achieved with ferumoxytol.