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Cai and Hernandez Developing New Ways to Gauge Diabetes Progression, Treatment

Posted on Aug 11, 2017

Baseline PET scan shows uptake of manganese chloride tracer in mouse pancreas, in research at the University of Wisconsin–Madison department of radiology. Signal is greatly reduced in mice given a drug that inhibits insulin production, and conversely, intensified in mice given a stimulator of insulin production. REINIER HERNANDEZ, UW–MADISON

A promising new method for gauging diabetes progression and treatment is featured in the August issue of the journal Diabetes.

Researchers at the University of Wisconsin–Madison have developed a new measurement for the volume and activity of beta cells, the source of the sugar-regulating hormone insulin.

In a study published in the August edition of the journal Diabetes, Weibo Cai and colleagues used a PET scanner to detect minute levels of a radioactive chemical in the mouse pancreas. Cai, the senior author of the study and an associate professor of radiology, says that unlike previous methods for measuring the quantity of beta cells, the new test also measures how actively these cells are making insulin.

PET scanning, or positron emission tomography, is used to detect minute quantities of tracers, commonly for finding cancer and metastases. This area is a specialty of Cai. Cai says the test may be used to evaluate treatments or cell transplants intended to slow or reverse diabetes.
Read more about it at news.wisc.edu, or see the full published article at diabetesjournals.org.



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